When you say "significance of sin is disease in the body or disturbance in the mind", does this mean all diseases must be wiped out in order to attain Jeeva-samadhi?

Vethathiri Maharishi answer: Even if there is disease or permanent damage to some part which gives pain, it will not affect the mind.
By understanding or fixing the mind with the supreme force, the mental state completely changes.
Thoughts abate a does action. In such a way, all the sinful imprints, unwanted imprints, will be neutralised.